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Literature summary extracted from

  • Sankaran, L.; Pogell, B.M.
    Biosynthesis of puromycin in Streptomyces alboniger: regulation and properties of O-demethylpuromycin O-methyltransferase (1975), Antimicrob. Agents Chemother., 8, 721-732.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.1.1.38 stabilized by addition of S-adenosyl-L-methionine Streptomyces alboniger

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.38 D-glucose reduced enzyme form, represses puromycin synthesis Streptomyces alboniger
2.1.1.38 puromycin
-
 Streptomyces alboniger

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.38 S-adenosyl-L-methionine + O-demethylpuromycin Streptomyces alboniger
-
 S-adenosyl-L-homocysteine + puromycin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.38 Streptomyces alboniger
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.38
-
 Streptomyces alboniger

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.38 S-adenosyl-L-methionine + O-demethylpuromycin
-
 Streptomyces alboniger S-adenosyl-L-homocysteine + puromycin
-
 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
2.1.1.38 37
-
 rapidly inactivated at 37°C, very unstable even at low temperatures, enzyme activity is destroyed upon boiling Streptomyces alboniger